Impacts of ivermectin mass drug administration for onchocerciasis on mosquito populations of Ogun state, Nigeria

Abstract Background The impact of single-dose mass drug administration (MDA) ivermectin for onchocerciasis on mosquito populations was investigated in Ogun State, Nigeria. Methods Indoor and outdoor collection mosquitoes carried out two intervention (IC) control communities (CC) at three different periods: pre-MDA (baseline), 2–3 days after MDA 13–14 MDA. density parity rate female Anopheles Culex were determined compared. Environmental climatic data study locations obtained to perform generalized linear model analysis. Results A total 1399 collected, including 1227 172 mosquitoes. There a similar magnitude reduction the indoor by 29% IC CC post-MDA but significantly higher ( p = 0.021) IC, reducing more than 50%. In observation significant consistent both (1.43 1.02) (95.35% 44.26%) remained reduced (75.86%) post-MDA. On other hand, increased from 0.07 0.10 while did not change. 0.394) 0.58 0.90 post-MDA; (2.83 3.90) (70.59% 97.44%) , 85.71 66.67% showed that caused < 0.001) 0.003) IC. Conclusion Ivermectin resulted survival This has strong implications malaria transmission, which depends strongly vector survival. Graphic abstract